The Northern Alberta Stollery's Children Foundation was established in 1978 in Edmonton, Alberta. In 1992, the name was changed to Children's Health Foundation of Northern Alberta, this was to reflect on teh role of the Foundation where funds were raised to support regional Child Health Care. Over the next seven years, the Foundation was helping to benefit for specialized services provided by the Child Health Program across Canada. In 1999, the name was changed to Children's Health Foundation.

With the generous support received by the people in the community, over $10 million was raised towards building a children's hospital in Edmonton, Alberta. In 1991, the Stollery's Children Hospital was the only hospital in Edmonton whose foundation was not specified to supporting the needs of children.